Potential Beneficial Effects of <em>Chenopodium quinoa</em> and <em>Salvia hispanica</em> L. in Glucose Homeostasis in Hyperglycemic Mice Model

Abstract

Impaired glucose homeostasis is associated with an increased risk of developing metabolic alterations. In this study, a model in which mice treated with streptozotocin were fed a high-fat diet was used to mimic early stages of the onset of metabolic disorders, and different bread formulations were administrated to evaluate the effect of replacing wheat flour with Chenopodium quinoa (Q) (25%) and Salvia hispanica L. (Sh) (20%). Plasmatic glucose and insulin concentrations were quantified and the homeostasis model assessment (HOMAir) was calculated. Q and Sh showed a lower tendency to hyperglycemia compared to wheat bread (WB). Besides, these low glucose levels were accompanied by three-fold lower values of HOMAir respect to WB, suggesting an improved insulin sensitivity. Thus, inclusion of C. quinoa and S. hispanica into bread formulations could improve the control of glucose homeostasis, which could help to prevent/ameliorate metabolic glucose alterations.

Keywords

• <em>Chenopodium quinoa</em>
• <em>Salvia hispanica</em> L.
• hyperglycemia
• HOMAir