Nature Communications (Jul 2019)
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
- Rocío Rojo,
- Anna Raper,
- Derya D. Ozdemir,
- Lucas Lefevre,
- Kathleen Grabert,
- Evi Wollscheid-Lengeling,
- Barry Bradford,
- Melanie Caruso,
- Iveta Gazova,
- Alejandra Sánchez,
- Zofia M. Lisowski,
- Joana Alves,
- Irene Molina-Gonzalez,
- Hayk Davtyan,
- Rebecca J. Lodge,
- James D. Glover,
- Robert Wallace,
- David A. D. Munro,
- Eyal David,
- Ido Amit,
- Véronique E. Miron,
- Josef Priller,
- Stephen J. Jenkins,
- Giles E. Hardingham,
- Mathew Blurton-Jones,
- Neil A. Mabbott,
- Kim M. Summers,
- Peter Hohenstein,
- David A. Hume,
- Clare Pridans
Affiliations
- Rocío Rojo
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Anna Raper
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Derya D. Ozdemir
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Lucas Lefevre
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Kathleen Grabert
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Evi Wollscheid-Lengeling
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Barry Bradford
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Melanie Caruso
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Iveta Gazova
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Alejandra Sánchez
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Zofia M. Lisowski
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Joana Alves
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Irene Molina-Gonzalez
- The MRC University of Edinburgh Centre for Reproductive Health, The Queen’s Medical Research Institute
- Hayk Davtyan
- Department of Neurobiology and Behavior, University of California Irvine
- Rebecca J. Lodge
- University of Edinburgh Centre for Inflammation Research, The Queen’s Medical Research Institute
- James D. Glover
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Robert Wallace
- The Department of Orthopedic Surgery, University of Edinburgh
- David A. D. Munro
- UK Dementia Research Institute, The University of Edinburgh
- Eyal David
- Department of Immunology, Weizmann Institute of Science
- Ido Amit
- Department of Immunology, Weizmann Institute of Science
- Véronique E. Miron
- The MRC University of Edinburgh Centre for Reproductive Health, The Queen’s Medical Research Institute
- Josef Priller
- UK Dementia Research Institute, The University of Edinburgh
- Stephen J. Jenkins
- University of Edinburgh Centre for Inflammation Research, The Queen’s Medical Research Institute
- Giles E. Hardingham
- UK Dementia Research Institute, The University of Edinburgh
- Mathew Blurton-Jones
- Department of Neurobiology and Behavior, University of California Irvine
- Neil A. Mabbott
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- Kim M. Summers
- Mater Research Institute-University of Queensland, Translational Research Institute
- Peter Hohenstein
- The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush
- David A. Hume
- Mater Research Institute-University of Queensland, Translational Research Institute
- Clare Pridans
- University of Edinburgh Centre for Inflammation Research, The Queen’s Medical Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-11053-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
The lineage-specific receptor CSF1R controls macrophage development and homeostasis. Here the authors show that deletion of a conserved Csf1r enhancer (FIRE) selectively depletes brain microglia and resident macrophages in the epidermis, kidney, heart and peritoneum of otherwise healthy mice.
