Update on transfusion solutions during surgery: review of hydroxyethyl starches 130/0.4

Abstract

Ornella Piazza , Giuliana Scarpati , Rosalba TufanoAnaesthesia and Intensive Care, University of Naples Federico II, School of Medicine, Naples, Italy Objectives: Restoration of circulation is crucial in the surgical patient management. Colloids and crystalloids are widely used for blood volume therapy. We reviewed recent trials to evaluate efficacy and safety of hydroxyethyl starch (HES) 130/0.4 during surgery.Material and methods: A subjective, not systematic, review of literature was performed. Papers were searched to answer questions about efficacy of HES, its impact on coagulation and inflammation and its effects on pulmonary mechanics and renal function.Conclusions: HES 130/0.4 is effective for volume therapy and is less expensive than human albumin. Its effects on coagulation and renal function are manageable; it may ameliorate pulmonary permeability and reduce inflammation.Keywords: HES, colloids, volume loading, coagulation, inflammation, surgery, renal function, pulmonary mechanics