Small field proton irradiation for in vivo studies: Potential and limitations when adapting clinical infrastructure

Abstract

Purpose: To evaluate the dosimetric accuracy for small field proton irradiation relevant for pre-clinical in vivo studies using clinical infrastructure and technology. In this context additional beam collimation and range reduction was implemented. Methods and materials: The clinical proton beam line employing pencil beam scanning (PBS) was adapted for the irradiation of small fields at shallow depths. Cylindrical collimators with apertures of 15, 12, 7 and 5 mm as well as two different range shifter types, placed at different distances relative to the target, were tested: a bolus range shifter (BRS) attached to the collimator and a clinical nozzle mounted range shifter (CRS) placed at a distance of 72 cm from the collimator. The Monte Carlo (MC) based dose calculation engine implemented in the clinical treatment planning system (TPS) was commissioned for these two additional hardware components. The study was conducted with a phantom and cylindrical target sizes between 2 and 25 mm in diameter following a dosimetric end-to-end test concept. Results: The setup with the CRS provided a uniform dose distribution across the target. An agreement of better than 5% between the planned dose and the measurements was obtained for a target with 3 mm diameter (collimator 5 mm). A 2 mm difference between the collimator and the target diameter (target being 2 mm smaller than the collimator) sufficed to cover the whole target with the planned dose in the setup with CRS. Using the BRS setup (target 8 mm, collimator 12 mm) resulted in non-homogeneous dose distributions, with a dose discrepancy of up to 10% between the planned and measured doses. Conclusion: The clinical proton infrastructure with adequate beam line adaptations and a state-of-the-art TPS based on MC dose calculations enables small animal irradiations with a high dosimetric precision and accuracy for target sizes down to 3 mm.

Keywords

• Small field irradiation
• Proton pencil beam scanning
• Pre-clinical in vivo studies
• Clinical infrastructure
• Collimator
• Dosimetry