Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor

Masahiro Tomioka; Yasuki Naito; Hidehito Kuroyanagi; Yuichi Iino

doi:10.1038/ncomms11645

Nature Communications (May 2016)

Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor

Masahiro Tomioka,
Yasuki Naito,
Hidehito Kuroyanagi,
Yuichi Iino

Affiliations

Masahiro Tomioka: Molecular Genetics Research Laboratory, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Yasuki Naito: Molecular Genetics Research Laboratory, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
Hidehito Kuroyanagi: Laboratory of Gene Expression, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan
Yuichi Iino: Molecular Genetics Research Laboratory, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan

DOI: https://doi.org/10.1038/ncomms11645
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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Little is known about the molecular mechanisms regulating neuron-specific alternative splicing. Here, the authors identify a combination of RNA-binding proteins regulating neuron-specific expression of the C. elegansinsulin receptor isoform DAF-2c and find disrupting these factors leads to learning deficits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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