Nature Communications (Oct 2020)

Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin

  • Hongzhe Sun,
  • Qi Zhang,
  • Runming Wang,
  • Haibo Wang,
  • Yuen-Ting Wong,
  • Minji Wang,
  • Quan Hao,
  • Aixin Yan,
  • Richard Yi-Tsun Kao,
  • Pak-Leung Ho,
  • Hongyan Li

DOI
https://doi.org/10.1038/s41467-020-18939-y
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

Read online

Multi-drug resistant pathogens remain a serious public health threat. Here, Sun and colleagues identify a role for auranofin, which is normally used as a drug for rheumatoid arthritis, for reversing antibiotic resistance to carbapenem and colistin.