Current approaches to the treatment of complicated pyelonephritis: protected cephalosporin use, including the combination of ceftriaxone/sulbactam

Abstract

Infections of the urinary system occupy a leading place among nephrology pathology and infectious diseases in general, in particular, constitute a significant proportion of infections multiresistant microorganisms. The topic of this article is devoted to the etiology and the key stages of the pathogenesis of infectious lesions of the urinary system, particularly complicated pyelonephritis, as well as the comparative characteristics of drugs used in the treatment of these patients. The main part of the article is an analysis of pharmacodynamics, efficacy, safety and expediency of the combined antimicrobial drug ceftriaxone/sulbactam.

Keywords

• urinary tract infections
• pyelonephritis
• multi-drug resistance
• ceftriaxone
• sulbactam