Nature Communications (Jul 2019)

Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life

  • Kyriel M. Pineault,
  • Jane Y. Song,
  • Kenneth M. Kozloff,
  • Daniel Lucas,
  • Deneen M. Wellik

DOI
https://doi.org/10.1038/s41467-019-11100-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Prior evidence suggested mesenchymal stromal cells (MSCs) required for skeletal formation, maintenance, and repair arise postnatally. Here, the authors show that Hoxa11 lineage-marked cells give rise to all skeletal lineages from embryogenesis through adulthood and are upstream progenitors of LepR- and Osx-lineage MSCs