Nature Communications (Dec 2021)
CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease
- Yi Duan,
- Huikuan Chu,
- Katharina Brandl,
- Lu Jiang,
- Suling Zeng,
- Nairika Meshgin,
- Eleni Papachristoforou,
- Josepmaria Argemi,
- Beatriz G. Mendes,
- Yanhan Wang,
- Hua Su,
- Weizhong Sun,
- Cristina Llorente,
- Tim Hendrikx,
- Xiao Liu,
- Mojgan Hosseini,
- Tatiana Kisseleva,
- David A. Brenner,
- Ramon Bataller,
- Prakash Ramachandran,
- Michael Karin,
- Wenxian Fu,
- Bernd Schnabl
Affiliations
- Yi Duan
- Department of Medicine, University of California San Diego
- Huikuan Chu
- Department of Medicine, University of California San Diego
- Katharina Brandl
- Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
- Lu Jiang
- Department of Medicine, University of California San Diego
- Suling Zeng
- Department of Medicine, University of California San Diego
- Nairika Meshgin
- Department of Medicine, University of California San Diego
- Eleni Papachristoforou
- University of Edinburgh Centre for Inflammation Research, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Josepmaria Argemi
- Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh Liver Research Center
- Beatriz G. Mendes
- Department of Medicine, University of California San Diego
- Yanhan Wang
- Department of Medicine, University of California San Diego
- Hua Su
- Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego
- Weizhong Sun
- Department of Medicine, University of California San Diego
- Cristina Llorente
- Department of Medicine, University of California San Diego
- Tim Hendrikx
- Department of Medicine, University of California San Diego
- Xiao Liu
- Department of Medicine, University of California San Diego
- Mojgan Hosseini
- Department of Pathology, University of California San Diego
- Tatiana Kisseleva
- Department of Surgery, University of California San Diego
- David A. Brenner
- Department of Medicine, University of California San Diego
- Ramon Bataller
- Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh Liver Research Center
- Prakash Ramachandran
- University of Edinburgh Centre for Inflammation Research, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Michael Karin
- Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego
- Wenxian Fu
- Department of Pediatrics, University of California San Diego
- Bernd Schnabl
- Department of Medicine, University of California San Diego
- DOI
- https://doi.org/10.1038/s41467-021-27385-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
CRIg is expressed on liver macrophages and binds Gram-positive bacteria to mediate phagocytosis, but it is not clear how its phagocytic functions contribute to liver homeostasis or disease. Here the authors report that ethanol impairs hepatic clearance of translocated pathobionts, via decreased hepatic CRIg, which facilitates progression of alcoholic liver disease.
