Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase

Chinnu Rose Joseph; Sabrina Dusi; Michele Giannattasio; Dana Branzei

doi:10.1038/s41467-022-30215-9

Nature Communications (May 2022)

Rad51-mediated replication of damaged templates relies on monoSUMOylated DDK kinase

Chinnu Rose Joseph,
Sabrina Dusi,
Michele Giannattasio,
Dana Branzei

Affiliations

Chinnu Rose Joseph: IFOM, Istituto Fondazione di Oncologia Molecolare
Sabrina Dusi: IFOM, Istituto Fondazione di Oncologia Molecolare
Michele Giannattasio: IFOM, Istituto Fondazione di Oncologia Molecolare
Dana Branzei: IFOM, Istituto Fondazione di Oncologia Molecolare

DOI: https://doi.org/10.1038/s41467-022-30215-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Joseph et al. reveal that monoSUMOylated DDK kinase, implicated in replication initiation, acts with Rad51 recombinase to prevent replication fork uncoupling and to mediate recombination-dependent gap-filling in the presence of genotoxic stress.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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