Subclinical decrease in cardiac autonomic and diastolic function in patients with metabolic disorders: HSCAA study

Abstract

Heart failure due to decreased diastolic function, HFpEF, is a growing health concern with rising prevalence. We examined subclinical cardiac autonomic and diastolic functions in 605 patients with metabolic diseases classified as pre-heart failure. Presence of glucose intolerance or diabetes, or visceral adiposity was significantly associated with reduced cardiac autonomic and diastolic functions. Higher autonomic functions were significantly associated with a parameter of better cardiac diastolic function (E/A) (SDNN: r = 0.306, p < 0.01; HF: r = 0.341, p < 0.01), with the association independent of diabetes, body mass index, visceral adiposity and insulin resistance index. Thus, reduced autonomic function may be a potential predictor for decreased cardiac diastolic functions in metabolic disorders. Keywords: Cardiac diastolic dysfunction, Heart rate variability, Parasympathetic activity, Glucose tolerance, Diabetes, Insulin resistance, Adiposity, Visceral obesity