Revista Cubana de Investigaciones Biomédicas (Mar 2007)
Niveles de vitaminas antioxidantes en plasma de pacientes con infarto de miocardio Levels of antioxidant vitamins in plasma from patients with myocardial infarction
Abstract
Se evaluó la posible asociación entre niveles séricos deficientes de vitamina E, C y A con la presencia de infarto de miocardio y el hábito de fumar. Se seleccionó una muestra compuesta por 34 casos con un primer infarto de miocardio. Los controles se tomaron al azar en el último mes de cada trimestre con un total de 61 personas. Se determinaron los niveles séricos de vitamina E, C y A y lipidograma. Se evaluó el hábito de fumar como factor en la influencia de las concentraciones de vitaminas y los antecedentes de hipertensión arterial. De los casos, 93,3 %, y de los controles, 59,3 %, fumaron alguna vez durante su vida. Las medias de los valores de vitamina C plasmáticos fueron significativamente superiores en los controles en relación con los casos (pThe possible association between the deficient serum levels of vitamins E, C and A with the presence of myocardial infarction and smoking habit is evaluated. A sample composed of 34 patients with a first myocardial infarction was selected. The controls, 61 in all, were taken at random in the last month of every quarter. The serum levels of vitamins E, C and A were determined and a lipid profile was performed. The smoking habit was evaluated as a factor in the influence of vitamin concentrations and the history of arterial hypertension. 93.3 % of the cases and 59.3 % of the controls smoked once in their lives. The means of the plasmatic vitamin C values were significantly higher in the control compared with the cases (p< 0,001). It was not so with the values of vitamin A (retinol) and E (α tocoferol) found. The association of the myocardial infarction with the vitamin C deficiency was marked with OR =5.95 and CI =1.27 - 36.84. It was not observed a significant association with the deficiency of α tocoferol OR =1.89 CI=0.72 - 5.05. The analysis of the association between the vitamin C deficiency and the smoking habit was remarkable with p= 0.009, but the association of the α tocoferol deficiency with the smoking habit was not significant (p=0.691). No vitamin A deficiencies were detected.
