Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Wei Zhang; Tianjiao Ji; Yang Li; Yueqin Zheng; Manisha Mehta; Chao Zhao; Andong Liu; Daniel S. Kohane

doi:10.1038/s41467-020-16177-w

Nature Communications (May 2020)

Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Wei Zhang,
Tianjiao Ji,
Yang Li,
Yueqin Zheng,
Manisha Mehta,
Chao Zhao,
Andong Liu,
Daniel S. Kohane

Affiliations

Wei Zhang: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Tianjiao Ji: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Yang Li: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Yueqin Zheng: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Manisha Mehta: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Chao Zhao: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Andong Liu: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Daniel S. Kohane: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-16177-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

Read online

Local anesthetic sustained release systems suffer from untriggered rapid drug release upon application. Here the authors overcome this issue by covalently linking tetracaine to a polymer gel via a photo-cleavable linkage, enabling light-triggered and repeatable drug release.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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