5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

R. Blake Billmyre; Shelly Applen Clancey; Lucy X. Li; Tamara L. Doering; Joseph Heitman

doi:10.1038/s41467-019-13890-z

Nature Communications (Jan 2020)

5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

R. Blake Billmyre,
Shelly Applen Clancey,
Lucy X. Li,
Tamara L. Doering,
Joseph Heitman

Affiliations

R. Blake Billmyre: Department of Molecular Genetics and Microbiology, Duke University Medical Center
Shelly Applen Clancey: Department of Molecular Genetics and Microbiology, Duke University Medical Center
Lucy X. Li: Department of Molecular Microbiology, Washington University School of Medicine
Tamara L. Doering: Department of Molecular Microbiology, Washington University School of Medicine
Joseph Heitman: Department of Molecular Genetics and Microbiology, Duke University Medical Center

DOI: https://doi.org/10.1038/s41467-019-13890-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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The authors show that resistance to the antifungal 5-fluorocytosine in Cryptococcus deuterogattii is acquired more frequently in isolates with elevated mutation rate, and is associated with alterations in capsule biosynthesis and nucleotide metabolism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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