Wilson’s Disease Presenting with Generalized Tonic-Clonic Seizure and Cerebellar Dysfunction

Abstract

Aziz Rahman Rasib,1 Aemal Aziz Jabarkhil,1 Mohammad Faiq Sediqi,2,3 Ahmad Irshad Mansoor,1,4 Abdullah Asady5 1Department of Neuropsychiatry, Kabul University of Medical Sciences, Kabul, 1001, Afghanistan; 2Department of Histology, Kabul University of Medical Sciences, Kabul, 1001, Afghanistan; 3Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan, 25200, Malaysia; 4Division of Psychology & Systems Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London and London School of Hygiene and Tropical Medicine, London, UK; 5Department of Microbiology, Kabul University of Medical Sciences, Kabul, 1001, AfghanistanCorrespondence: Aziz Rahman RasibDepartment of Neuropsychiatry, Kabul University of Medical Sciences, Kabul, 1001, AfghanistanTel [phone]Email [email protected]: Wilson’s disease (WD) is a rare inherited impaired copper metabolism with diverse clinical pictures dominated by hepatic and neurologic manifestations. We report the case of a 14-year-old female patient who attended the Department of Neuropsychiatry at Ali Abad Teaching Hospital, Kabul, Afghanistan, with generalized tonic-clonic seizure and cerebellar dysfunction. The patient was initially diagnosed as encephalitis and epilepsy and finally diagnosed with WD based on the clinical and laboratory findings. After 6 months of follow-up, the patient showed substantial clinical recovery.Keywords: Wilson’s disease, copper accumulation, KF rings, seizure, cerebellar dysfunction

Keywords

• wilson’s disease
• copper accumulation
• kf rings
• seizure
• cerebellar dysfunction