Self−Assembling Anchorage of Hyaluronic Acid on the Nanoparticle Surface Confers Superiority of Triple Negative Breast Cancer Treatment
Yingpeng Li,
Liang Liu,
Hongtao Shang,
Xuchen Feng,
Ni Fan,
Jingyu Wang,
Yuqi Wu,
Yatong Chen,
Xinhong Chu,
Min Zhong,
Yujiao Sun,
Hui Fu,
Wei Huang,
Yunfei Li
Affiliations
Yingpeng Li
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Liang Liu
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Hongtao Shang
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Xuchen Feng
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Ni Fan
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Jingyu Wang
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Yuqi Wu
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Yatong Chen
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Xinhong Chu
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Min Zhong
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Yujiao Sun
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Hui Fu
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Wei Huang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Yunfei Li
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Triple-negative breast cancer (TNBC) has been listed as one of the most fatal diseases, and no effective targeting treatment is clinically available. Although CD44-targeting hyaluronic acid (HA) has been utilized as targeting ligands in many studies, no facile ways have been developed through HA self-assembly at the nanoparticle surface. Herein, we reported N-isopropylacrylamide-grafted chitosan-based nanoparticles self-assembling with HA (HA-NPs) through electrostatic forces and loaded with curcumin (CUR). The HA-NPs displayed pH-responsive properties due to the chemical modification of chitosan, and the preparation process was optimized by central composite design–response surface methodology. HA anchorage confers the vehicle with tumor-targeting capability. HA-NPs displayed more robust effects of inhibiting TNBC primary tumor growth than free CUR and a plain counterpart but without increased systemic cytotoxicity. In addition, in vivo pharmacokinetic studies showed that HA-NPs significantly increased the in vivo residence time of free CUR and improved the bioavailability of CUR. These findings suggested that chitosan-based HA-NPs may provide a feasible and unique strategy to achieve CD44 targeting and enhance its efficacy in vivo for the treatment of advanced TNBC.
