Can Sepsis-induced Coagulopathy Scores and Routine Blood Tests Indicate Prognosis in Patients with COVID-19?

Abstract

Objective:Coronavirus disease-19 (COVID-19) is a multisystemic disease and prognostic factors should be well defined to assess its severity. Sepsis-induced coagulopathy (SIC) score is calculated using parameters related to cardiac, renal, gastrointestinal, and central nervous systems, and coagulation. In this study, we investigated the prognostic effectiveness of the SIC score during the follow-up of patients with COVID-19.Methods:The study was conducted retrospectively by evaluating 123 patients diagnosed as having COVID-19 and hospitalized in the intensive care unit. Patients were divided into two groups, low-risk and high-risk, according to their calculated SIC scores. Patients in these groups were compared in terms of laboratory parameters and outcome patterns.Results:The rate of in-hospital deaths was higher in the group with positive SIC scores compared to the group with negative scores. In the positive-SIC (high-risk) group, albumin level was 2.6±0.6 g/dL, the neutrophil-lymphocyte ratio was 13.6±13.8%, and prothrombin time (PT) was 18.2±2.8. The difference between the values obtained in the comparison between the groups was found to be statistically significant.Conclusion:The SIC score can be used to predict in-hospital mortality in patients wi the COVID-19. Serum albumin level was shown to have a significant association with poor prognosis in our study. An increase in the neutrophil-lymphocyte ratio, which is a cheap, easily measured, and reproducible parameter, can be used as an indicator of poor prognosis. PT was prolonged by 4 seconds over the normal value in our study. PT prolongation may be associated with mortality. SIC score can serve as a marker of disease severity.

Keywords

• covid-19
• sepsis-induced coagulopathy score
• prognosis