Impact of SOX2 function and regulation on therapy resistance in bladder cancer

Guodong Chen; Guodong Chen; Guodong Chen; Yan Chen; Ruiquan Xu; Ruiquan Xu; Guoxi Zhang; Guoxi Zhang; Xiaofeng Zou; Xiaofeng Zou; Gengqing Wu; Gengqing Wu

doi:10.3389/fonc.2022.1020675

Frontiers in Oncology (Nov 2022)

Impact of SOX2 function and regulation on therapy resistance in bladder cancer

Guodong Chen,
Guodong Chen,
Guodong Chen,
Yan Chen,
Ruiquan Xu,
Ruiquan Xu,
Guoxi Zhang,
Guoxi Zhang,
Xiaofeng Zou,
Xiaofeng Zou,
Gengqing Wu,
Gengqing Wu

Affiliations

Guodong Chen: The First Clinical College, Gannan Medical University, Ganzhou, China
Guodong Chen: Department of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China
Guodong Chen: Institute of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China
Yan Chen: Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
Ruiquan Xu: Department of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China
Ruiquan Xu: Institute of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China
Guoxi Zhang: Department of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China
Guoxi Zhang: Institute of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China
Xiaofeng Zou: Department of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China
Xiaofeng Zou: Institute of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China
Gengqing Wu: Department of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China
Gengqing Wu: Institute of Urology, Affiliated Hospital of Gannan Medical University, Ganzhou, China

DOI: https://doi.org/10.3389/fonc.2022.1020675
Journal volume & issue: Vol. 12

Abstract

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Bladder cancer (BC) is a malignant disease with high rates of recurrence and mortality. It is mainly classified as non-muscle-invasive BC and muscle-invasive BC (MIBC). Often, MIBC is chemoresistant, which, according to cancer stem cells (CSCs) theory, is linked to the presence of bladder cancer stem cells (BCSCs). Sex-determining region Y- (SRY) Box transcription factor 2 (SOX2), which is a molecular marker of BCSCs, is aberrantly over-expressed in chemoresistant BC cell lines. It is one of the standalone prognostic factors for BC, and it has an inherently significant function in the emergence and progression of the disease. This review first summarizes the role of SRY-related high-mobility group protein Box (SOX) family genes in BC, focusing on the SOX2 and its significance in BC. Second, it discusses the mechanisms relevant to the regulation of SOX2. Finally, it summarizes the signaling pathways related to SOX2 in BC, suggests current issues to be addressed, and proposes potential directions for future research to provide new insights for the treatment of BC.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

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