Scientific Reports (Jan 2025)
Geriatric nutritional risk index and newly developed scoring system as prognosis prediction for unresectable hepatocellular carcinoma patients treated with lenvatinib
- Hideko Ohama,
- Atsushi Hiraoka,
- Toshifumi Tada,
- Masashi Hirooka,
- Kazuya Kariyama,
- Joji Tani,
- Masanori Atsukawa,
- Koichi Takaguchi,
- Ei Itobayashi,
- Shinya Fukunishi,
- Kunihiko Tsuji,
- Toru Ishikawa,
- Kazuto Tajiri,
- Hironori Ochi,
- Satoshi Yasuda,
- Hidenori Toyoda,
- Chikara Ogawa,
- Takashi Nishimura,
- Takeshi Hatanaka,
- Satoru Kakizaki,
- Noritomo Shimada,
- Kazuhito Kawata,
- Atsushi Naganuma,
- Hisashi Kosaka,
- Tomomitsu Matono,
- Hidekatsu Kuroda,
- Yutaka Yata,
- Hironori Tanaka,
- Hiroki Nishikawa,
- Hiroshi Shibata,
- Fujimasa Tada,
- Kazuhiro Nouso,
- Asahiro Morishita,
- Akemi Tsutsui,
- Takuya Nagano,
- Norio Itokawa,
- Tomomi Okubo,
- Taeang Arai,
- Michitaka Imai,
- Yohei Koizumi,
- Shinichiro Nakamura,
- Hiroko Iijima,
- Masaki Kaibori,
- Yoichi Hiasa,
- Takashi Kumada
Affiliations
- Hideko Ohama
- Gastroenterology Center, Ehime Prefectural Central Hospital
- Atsushi Hiraoka
- Gastroenterology Center, Ehime Prefectural Central Hospital
- Toshifumi Tada
- Department of Internal Medicine, Japanese Red Cross Himeji Hospital
- Masashi Hirooka
- Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
- Kazuya Kariyama
- Department of Gastroenterology, Okayama City Hospital
- Joji Tani
- Department of Gastroenterology and Neurology, Kagawa University
- Masanori Atsukawa
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School
- Koichi Takaguchi
- Department of Hepatology, Kagawa Prefectural Central Hospital
- Ei Itobayashi
- Department of Gastroenterology, Asahi General Hospital
- Shinya Fukunishi
- Department of Gastroenterology, Hyogo Medical University
- Kunihiko Tsuji
- Center for Gastroenterology, Teine Keijinkai Hospital
- Toru Ishikawa
- Department of Gastroenterology, Saiseikai Niigata Hospital
- Kazuto Tajiri
- Department of Gastroenterology, Toyama University Hospital
- Hironori Ochi
- Center for Liver- Biliary- Pancreatic Disease, Matsuyama Red Cross Hospital
- Satoshi Yasuda
- Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital
- Hidenori Toyoda
- Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital
- Chikara Ogawa
- Department of Gastroenterology, Japanese Red Cross Takamatsu Hospital
- Takashi Nishimura
- Department of Gastroenterology, Hyogo Medical University
- Takeshi Hatanaka
- Department of Gastroenterology, Gunma Saiseikai Maebashi Hospital
- Satoru Kakizaki
- Department of Clinical Research, NHO Takasaki General Medical Center
- Noritomo Shimada
- Division of Gastroenterology and Hepatology, Otakanomori Hospital
- Kazuhito Kawata
- Hepatology Division, Department of Internal Medicine II, Hamamatsu University School of Medicine
- Atsushi Naganuma
- Department of Gastroenterology, NHO Takasaki General Medical Center
- Hisashi Kosaka
- Department of Hepatobiliary Surgery, Kansai Medical University
- Tomomitsu Matono
- Department of Gastroenterology, Hyogo Prefectural Harima-Himeji General Medical Center
- Hidekatsu Kuroda
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, School of Medicine
- Yutaka Yata
- Department of Gastroenterology, Hanwa Memorial Hospital
- Hironori Tanaka
- Department of Gastroenterology, Takarazuka City Hospital
- Hiroki Nishikawa
- Department of Gastroenterology, Osaka Medical and Pharmaceutical University
- Hiroshi Shibata
- Department of Gastroenterology, Tokushima Prefectural Central Hospital
- Fujimasa Tada
- Gastroenterology Center, Ehime Prefectural Central Hospital
- Kazuhiro Nouso
- Department of Gastroenterology, Okayama City Hospital
- Asahiro Morishita
- Department of Gastroenterology and Neurology, Kagawa University
- Akemi Tsutsui
- Department of Hepatology, Kagawa Prefectural Central Hospital
- Takuya Nagano
- Department of Hepatology, Kagawa Prefectural Central Hospital
- Norio Itokawa
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School
- Tomomi Okubo
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School
- Taeang Arai
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School
- Michitaka Imai
- Department of Gastroenterology, Saiseikai Niigata Hospital
- Yohei Koizumi
- Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
- Shinichiro Nakamura
- Department of Internal Medicine, Japanese Red Cross Himeji Hospital
- Hiroko Iijima
- Department of Gastroenterology, Hyogo Medical University
- Masaki Kaibori
- Department of Hepatobiliary Surgery, Kansai Medical University
- Yoichi Hiasa
- Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
- Takashi Kumada
- Department of Nursing, Gifu Kyoritsu University
- DOI
- https://doi.org/10.1038/s41598-024-78539-4
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 11
Abstract
Abstract In the current era of immune therapy, lenvatinib (LEN) continues to be vital for treating unresectable hepatocellular carcinoma (uHCC) patients. This study investigates the importance of nutritional status in the prognosis of uHCC patients receiving LEN and evaluates a new prognostic scoring system that combines the geriatric nutritional risk index (GNRI) and systemic inflammatory response. From 2018 to 2022, 484 uHCC patients treated with LEN (384 males, median age 73). Prognostic value was compared between GNRI and C-reactive protein (CRP) scoring (GNRI-C score), GNRI, and neo-Glasgow prognostic score (neo-GPS). Evaluation was based on the Akaike information criterion (AIC) and concordance index(c-index). Median progression-free survival (mPFS) was 9.3/6.8/4.6 months for GNRI no-risk/low-risk/moderate-to-major risk (p < 0.01, AIC 4742.4/c-index 0.585). Median overall survival (mOS) was 27.8/15.2/9.5 months (p < 0.01, AIC 3433.34/c-index 0.639). For GNRI-C score, mPFS was 10.8/7.1/5.6/4.0 months (score 0/1/2/3) (p < 0.01, AIC 4732.82/c-index 0.6), while neo-GPS showed mPFS of 8.5/5.1/5.2 months (p < 0.01, AIC 4745.89/c-index 0.562). For mOS, GNRI-C score demonstrated 28.6/20.0/10.1/8.4 months (score 0/1/2/3) (p < 0.01, AIC 3420.27/c-index 0.652), while neo-GPS indicated 21.0/12.4/4.5 months (p < 0.01, AIC 3468.84/c-index 0.564). The newly devised GNRI-C score, incorporating nutritional and inflammatory markers, could offer improved prognostic predictions for uHCC patients treated with LEN.
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