Nature Communications (Jun 2020)
Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling
- Kun-Yang Lin,
- Wen-Der Wang,
- Chi-Hung Lin,
- Elham Rastegari,
- Yu-Han Su,
- Yu-Tzu Chang,
- Yung-Feng Liao,
- Yi-Chieh Chang,
- Haiwei Pi,
- Bo-Yi Yu,
- Shu-Hwa Chen,
- Chung-Yen Lin,
- Mei-Yeh Lu,
- Tsu-Yi Su,
- Fei-Yang Tzou,
- Chih-Chiang Chan,
- Hwei-Jan Hsu
Affiliations
- Kun-Yang Lin
- Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, National Chung Hsing University and Academia Sinica
- Wen-Der Wang
- Department of BioAgricultural Sciences, National Chiayi University
- Chi-Hung Lin
- Institute of Cellular and Organismic Biology, Academia Sinica
- Elham Rastegari
- Institute of Cellular and Organismic Biology, Academia Sinica
- Yu-Han Su
- Institute of Cellular and Organismic Biology, Academia Sinica
- Yu-Tzu Chang
- Institute of Cellular and Organismic Biology, Academia Sinica
- Yung-Feng Liao
- Institute of Cellular and Organismic Biology, Academia Sinica
- Yi-Chieh Chang
- Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kweishan
- Haiwei Pi
- Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Kweishan
- Bo-Yi Yu
- Institute of Information Science, Academia Sinica
- Shu-Hwa Chen
- Institute of Information Science, Academia Sinica
- Chung-Yen Lin
- Institute of Information Science, Academia Sinica
- Mei-Yeh Lu
- Biodiversity Research Center, Academia Sinica
- Tsu-Yi Su
- Graduate Institute of Physiology, College of Medicine, National Taiwan University
- Fei-Yang Tzou
- Graduate Institute of Physiology, College of Medicine, National Taiwan University
- Chih-Chiang Chan
- Graduate Institute of Physiology, College of Medicine, National Taiwan University
- Hwei-Jan Hsu
- Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, National Chung Hsing University and Academia Sinica
- DOI
- https://doi.org/10.1038/s41467-020-16858-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Retrotransposons are known to be involved in aging. Here the authors show that the retrotransposon silencer Piwi contributes to germline stem cell loss during aging in Drosophila.
