Faculty of Bio-Sciences, SBBUVAS, Sakrand 67210, Pakistan
Pavel Horky
Department of Animal Nutrition and Forage Production, Mendel University in Brno, 61300 Brno, Czech Republic
Syed Qamar Abbas
Department of Pharmacy, Sarhad University of Science and Technology, Peshawar 25000, Pakistan
Muhammad Majid
Department of Pharmacy, Capital University of Science and Technology, Islamabad 44000, Pakistan
Akram Hafiz Muhammad Bilal
Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
Fawad Ali
Department of Pharmacy, Kohat University of Science and Technology, Kohat 26000, Pakistan
Tapan Behl
Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, India
Syed Shams ul Hassan
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
Simona Bungau
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania
Ferroptosis is a recently described programmed cell death mechanism that is characterized by the buildup of iron (Fe)-dependent lipid peroxides in cells and is morphologically, biochemically, and genetically distinct from other forms of cell death, having emerged to play an important role in cancer biology. Ferroptosis has significant importance during cancer treatment because of the combination of factors, including suppression of the glutathione peroxidase 4 (Gpx4), cysteine deficiency, and arachidonoyl (AA) peroxidation, which cause cells to undergo ferroptosis. However, the physiological significance of ferroptosis throughout development is still not fully understood. This current review is focused on the factors and molecular mechanisms with the diagrammatic illustrations of ferroptosis that have a role in the initiation and sensitivity of ferroptosis in various malignancies. This knowledge will open a new road for research in oncology and cancer management.
