THE CORRELATION OF SERUM PREALBUMIN AND ROUTINE NUTRITION PARAMETERS IN CONTINUOUS AMBULATORY PERITONEAL DIALYSIS PATIENTS

Abstract

Prealbumin is evidenced to reflect recent dietary intake rather than overall nutrition status because of its short half-life. Most of continuous ambulatory peritoneal dialysis (CAPD) patients show hypoalbuminnemia. However, there are many factors which may influence the level of albumin in serum. We demonstrated the correlation of prealbumin and other common nutritional markers in CAPD patients. All participants were undergoing peritoneal dialysis more than 3 months with no active infection elsewhere. The participants were asked to do the handgrip strength (HGS) by Grip strength dynamometer (T.K.K.5001) and bioelectrical impedance analysis. Serum prealbumin, albumin and C-reactive protein (CRP) were tested. Of 48 patients, 56% had serum albumin less than 3.5g/dL (3.39±0.43) while prealbumin more than 0.35g/L (0.35±0.08). Sixty-eight percent of all participants had HGS below normal value according to gender. The correlation of prealbumin and the other nutrition parameters was shown in the table. prealbumin albumin HGS CRP lean body mass body cell mass prealbumin 1.000 0.484b 0.443b −0.419b −0.016 −0.012 albumin 0.484b 1.000 0.218 −0.347a 0.052 0.073 HGS 0.443c 0.218 1.000 −0.112 0.401 0.406a CRP −0.419b −0.347a −0.112 1.000 0.128 0.114 lean body mass −0.016 0.052 0.401 0.128 1.000 0.997b body cell mass −0.012 0.073 0.406a 0.114 0.997b 1.000 a p<0.05 b p<0.01 c p<0.001 We concluded that HGS may be a comfortably and non invasive alternative technique used to indicate nutrition status in CAPD patients.