Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

Abstract

The WD40 domain of ATG16L1 is thought to be involved in non-canonical autophagy. Here the authors screen peptide libraries and identify interactions between this domain and the IL-2Rγ and IL-10RB receptors, indicating endosomal regulation of cytokine signalling by non-canonical autophagy.