Communications Biology (May 2022)

Polarity protein SCRIB interacts with SLC3A2 to regulate proliferation and tamoxifen resistance in ER+ breast cancer

  • Yasuhiro Saito,
  • Shiori Matsuda,
  • Naomi Ohnishi,
  • Keiko Endo,
  • Sanae Ashitani,
  • Maki Ohishi,
  • Ayano Ueno,
  • Masaru Tomita,
  • Koji Ueda,
  • Tomoyoshi Soga,
  • Senthil K. Muthuswamy

DOI
https://doi.org/10.1038/s42003-022-03363-3
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 10

Abstract

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A complex involving polarity protein SCRIB and the leucine amino acid transporter SLC7A5 promotes cell proliferation and tamoxifen resistance in estrogen receptor-positive breast cancer cells.