Communications Biology (Dec 2020)
Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci
- Lvwen Ning,
- Josephine Mun-Yee Ko,
- Valen Zhuoyou Yu,
- Hoi Yan Ng,
- Candy King-Chi Chan,
- Lihua Tao,
- Shiu-Yeung Lam,
- Merrin Man-Long Leong,
- Roger Kai-Cheong Ngan,
- Dora Lai-Wan Kwong,
- Anne Wing-Mui Lee,
- Wai-Tong Ng,
- Ashley Cheng,
- Stewart Tung,
- Victor Ho-Fun Lee,
- Ka-On Lam,
- Chung-Kong Kwan,
- Wing-Sum Li,
- Stephen Yau,
- Jin-Xin Bei,
- Maria Li Lung
Affiliations
- Lvwen Ning
- Department of Clinical Oncology, University of Hong Kong
- Josephine Mun-Yee Ko
- Department of Clinical Oncology, University of Hong Kong
- Valen Zhuoyou Yu
- Department of Clinical Oncology, University of Hong Kong
- Hoi Yan Ng
- Department of Clinical Oncology, University of Hong Kong
- Candy King-Chi Chan
- Department of Clinical Oncology, University of Hong Kong
- Lihua Tao
- Department of Clinical Oncology, University of Hong Kong
- Shiu-Yeung Lam
- Department of Clinical Oncology, University of Hong Kong
- Merrin Man-Long Leong
- Department of Clinical Oncology, University of Hong Kong
- Roger Kai-Cheong Ngan
- Center for Nasopharyngeal Carcinoma Research, University of Hong Kong
- Dora Lai-Wan Kwong
- Department of Clinical Oncology, University of Hong Kong
- Anne Wing-Mui Lee
- Department of Clinical Oncology, University of Hong Kong
- Wai-Tong Ng
- Center for Nasopharyngeal Carcinoma Research, University of Hong Kong
- Ashley Cheng
- Center for Nasopharyngeal Carcinoma Research, University of Hong Kong
- Stewart Tung
- Center for Nasopharyngeal Carcinoma Research, University of Hong Kong
- Victor Ho-Fun Lee
- Department of Clinical Oncology, University of Hong Kong
- Ka-On Lam
- Department of Clinical Oncology, University of Hong Kong
- Chung-Kong Kwan
- Department of Clinical Oncology, Queen Elizabeth Hospital
- Wing-Sum Li
- Department of Clinical Oncology, Queen Elizabeth Hospital
- Stephen Yau
- Department of Clinical Oncology, Queen Elizabeth Hospital
- Jin-Xin Bei
- Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy
- Maria Li Lung
- Department of Clinical Oncology, University of Hong Kong
- DOI
- https://doi.org/10.1038/s42003-020-01487-y
- Journal volume & issue
-
Vol. 3,
no. 1
pp. 1 – 13
Abstract
Here the authors report a major histocompatibility complex (MHC) association analysis for nasopharyngeal carcinoma in Chinese individuals from Hong Kong, finding 8 independent associated loci associated with lower risk for developing nasopharyngeal carcinoma. Two non-human leukocyte antigen (HLA) genes are E3 ubiquitin ligases, TRIM31 and TRIM39, having a role in the innate immune response and implicating the importance of host Epstein-Barr virus interactions in this cancer.
