Clinical-Laboratory Significance of Myelofibrosis in Patients with Multiple Myeloma

Abstract

Background: Currently, there are not many studies of correlations between myelofibrosis (MF) and clinical-laboratory data on multiple myeloma (MM). Methods and Results: In our study, MF was evaluated according to the scale of the European consensus (2005). Additionally, we used an automated morphometric study. The inverse correlations between the prevalence of MF and the total number of erythroid cells and megakaryocytes, as well as hemoglobin level were found. The total relative area of fibrosis tissue (Srel.fibr.tis.) in initial and advanced MF>20% was associated with anemia requiring a blood transfusion.The development of severe anemia was observed in patients with a greater relative area of Srel.fibr.tis. The direct correlations between Srel.fibr.tis. and relative area of tumor tissue (Srel.tum.tis.), between Srel.fibr.tis. and the level of total serum protein, between Srel.fibr.tis. and daily proteinuria were found both in initial and in advanced MF. Additionally, a direct correlation between Srel.fibr.tis. and the number of plasma cells was revealed in initial MF. Greater Srel.fibr.tis. in initial and advanced MF was found in patients with chronic renal failure. Conclusion: The clinical-laboratory significance of MF in MM is an inhibition of erythroid cells and megakaryocytes and development of anemia. The relative area of fibrous tissue is a marker of tumor volume and tumor progression.

Keywords

• myelofibrosis ;
• multiple myeloma ;
• anemia;
• tumor progression.