Nature Communications (Feb 2022)
Placental genomics mediates genetic associations with complex health traits and disease
- Arjun Bhattacharya,
- Anastasia N. Freedman,
- Vennela Avula,
- Rebeca Harris,
- Weifang Liu,
- Calvin Pan,
- Aldons J. Lusis,
- Robert M. Joseph,
- Lisa Smeester,
- Hadley J. Hartwell,
- Karl C. K. Kuban,
- Carmen J. Marsit,
- Yun Li,
- T. Michael O’Shea,
- Rebecca C. Fry,
- Hudson P. Santos
Affiliations
- Arjun Bhattacharya
- Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California
- Anastasia N. Freedman
- Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina
- Vennela Avula
- Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina
- Rebeca Harris
- Biobehavioral Laboratory, School of Nursing, University of North Carolina
- Weifang Liu
- Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina
- Calvin Pan
- Department of Human Genetics, David Geffen School of Medicine, University of California
- Aldons J. Lusis
- Department of Human Genetics, David Geffen School of Medicine, University of California
- Robert M. Joseph
- Department of Anatomy and Neurobiology, Boston University School of Medicine
- Lisa Smeester
- Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina
- Hadley J. Hartwell
- Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina
- Karl C. K. Kuban
- Department of Pediatrics, Division of Pediatric Neurology, Boston University Medical Center
- Carmen J. Marsit
- Gangarosa Department of Environmental Health, Rollins School of Public Health Emory University
- Yun Li
- Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina
- T. Michael O’Shea
- Department of Pediatrics, School of Medicine, University of North Carolina
- Rebecca C. Fry
- Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina
- Hudson P. Santos
- Biobehavioral Laboratory, School of Nursing, University of North Carolina
- DOI
- https://doi.org/10.1038/s41467-022-28365-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The impact of placental transcriptomics on fetal traits throughout development is not well understood. Here, the authors apply distal-SNP-enriched transcriptome-wide association studies to detect genetic contributions, mediated through fetal placental genomics, to developmental programming of complex traits across the life course.
