C(sp3)−C(sp3) bond formation via nickel-catalyzed deoxygenative homo-coupling of aldehydes/ketones mediated by hydrazine

Dawei Cao; Chen-Chen Li; Huiying Zeng; Yong Peng; Chao-Jun Li

doi:10.1038/s41467-021-23971-7

Nature Communications (Jun 2021)

C(sp3)−C(sp3) bond formation via nickel-catalyzed deoxygenative homo-coupling of aldehydes/ketones mediated by hydrazine

Dawei Cao,
Chen-Chen Li,
Huiying Zeng,
Yong Peng,
Chao-Jun Li

Affiliations

Dawei Cao: Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University
Chen-Chen Li: Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University
Huiying Zeng: The State Key Laboratory of Applied Organic Chemistry, Lanzhou University
Yong Peng: Key Laboratory of Magnetism and Magnetic Materials of the Ministry of Education, School of Physical Science and Technology and Electron Microscopy Centre, Lanzhou University
Chao-Jun Li: Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University

DOI: https://doi.org/10.1038/s41467-021-23971-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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The direct deoxygenative coupling of aldehydes or ketones to construct C(sp3)−C(sp3) bond remains a scientific challenge. Here the authors use a nickel−catalyzed reductive homo-coupling of moisture- and air-stable hydrazones generated in-situ from naturally abundant aldehydes and ketones to construct challenging C(sp3)−C(sp3) bonds.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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