Viruses (Jun 2025)

The Role of Bacteriophage-Derived Small RNA Molecules in Bacterial and Phage Interactions

  • Natalia Lewandowska,
  • Sylwia Bloch,
  • Aleksandra Łukasiak,
  • Wojciech Wesołowski,
  • Grzegorz Węgrzyn,
  • Bożena Nejman-Faleńczyk

DOI
https://doi.org/10.3390/v17060834
Journal volume & issue
Vol. 17, no. 6
p. 834

Abstract

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Small regulatory RNAs (sRNAs) play a critical role in bacterial gene expression, modulating various cellular processes, including stress responses, metabolism, virulence, and many others. While well-characterized in bacterial systems, an emerging class of phage-derived sRNAs has been identified, suggesting an underexplored regulatory network at phage–host interactions. These sRNAs, encoded within phage genomes, influence both bacterial and viral life cycles by modulating transcriptional and post-transcriptional gene expression processes. The interplay between phage-derived sRNAs and the host genome reveals a complex network of gene regulation, with an impact on bacterial fitness, pathogenesis, and horizontal gene transfer. This review explores the diverse functions of phage-encoded sRNAs, highlighting recent discoveries and their impact on bacterial physiology and phage-host interactions.

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