Nature Communications (May 2021)

The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1

  • Sabrina Dietz,
  • Miguel Vasconcelos Almeida,
  • Emily Nischwitz,
  • Jan Schreier,
  • Nikenza Viceconte,
  • Albert Fradera-Sola,
  • Christian Renz,
  • Alejandro Ceron-Noriega,
  • Helle D. Ulrich,
  • Dennis Kappei,
  • René F. Ketting,
  • Falk Butter

DOI
https://doi.org/10.1038/s41467-021-22861-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

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Telomeres, tandem repeats at the ends of linear chromosomes, have evolved to deal with the end replication and end protection. Using a proteomics approach, the authors identify TEBP-1 and TEBP-2, two double-stranded binding proteins which together are required for fertility. Despite being paralogs, they have distinct individual effects on telomere dynamics; TEBP-1 and TEBP-2 are part of a telomeric complex also containing POT-1.