Investigation the Effect of Carbamazepine on Acquisition Passive Avoidance Learning in Male Rat Model of Seizure

Abstract

Introduction: Epilepsy is the most common disorder of the central nerves system. Patients suffering from epilepsy can experience a wide range of neuropsychological disorders such as impaired memory, disturbances in attention and information processing. Due to the effect of anticonvulsant carbamazepine and its effect on the memory and learning, the aim of this study was investigating the effect of Carbamazepine on passive avoidance learning in male rats seizure model. Methods: 30 male Wistar rats with an average weight of 230±20 g were used in the study. Animals were randomly divided into 5 groups. Seizure was induced by administration of pentylenetetrazole (PTZ: 60 mg/kg, ip). After induction of seizure the learning and memory of rats was tested in shuttle box. Latency to enter the dark room memory was evaluated as indicators of learning and memory. The data were analyzed by one way variance analysis and Tukey’s test using SPSS. Results: Pentylenetetrazole-induced seizures (PTZ) in acquisition group significantly reduced the latency to enter the dark room (P<0.01).  Carbamazepine significantly reduce the entrance time in intact rats and kindled rats by PTZ (P<0.05, P<0.01). Conclusion: This study showed that the administration of Carbamazepine in seizure rats can cause the increasing learning and memory impairments in rats by Pentylenetetrazole.

Keywords

• Carbamazepine
• Seizure
• Pentylenetetrazole
• Learning
• Memory
• Rat