A nanopore interface for higher bandwidth DNA computing

Karen Zhang; Yuan-Jyue Chen; Delaney Wilde; Kathryn Doroschak; Karin Strauss; Luis Ceze; Georg Seelig; Jeff Nivala

doi:10.1038/s41467-022-32526-3

Nature Communications (Aug 2022)

A nanopore interface for higher bandwidth DNA computing

Karen Zhang,
Yuan-Jyue Chen,
Delaney Wilde,
Kathryn Doroschak,
Karin Strauss,
Luis Ceze,
Georg Seelig,
Jeff Nivala

Affiliations

Karen Zhang: Paul G. Allen School of Computer Science and Engineering, University of Washington
Yuan-Jyue Chen: Microsoft Research
Delaney Wilde: Paul G. Allen School of Computer Science and Engineering, University of Washington
Kathryn Doroschak: Paul G. Allen School of Computer Science and Engineering, University of Washington
Karin Strauss: Microsoft Research
Luis Ceze: Paul G. Allen School of Computer Science and Engineering, University of Washington
Georg Seelig: Paul G. Allen School of Computer Science and Engineering, University of Washington
Jeff Nivala: Paul G. Allen School of Computer Science and Engineering, University of Washington

DOI: https://doi.org/10.1038/s41467-022-32526-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

Toe-hold-mediated strand displacement (DSD) is a widely used molecular tool in applications such as DNA computing and nucleic acid diagnostics. Here the authors characterize dozens of orthogonal barcode sequences that can be used for monitoring the output kinetics of multiplexed DSD reactions in real-time using a commercially-available portable nanopore array device.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal