THE STUDY OF MECHANISMS OF PHOTOINDUCED APOPTOSIS IN THE SKIN MALIGNANT MELANOMA CELL MODEL

M. L. Gelfond; I. A. Baldueva; A. S. Barchuk; G. I. Gafton; V. V. Anisimov; Yu. V. Semiletova; A. V. Novik; M. Yu. Myasnyankin; T. L. Nekhaeva; A. B. Danilova; E. V. Vorobeychikov; A. I. Vaalj; I. G. Gafton

doi:10.24931/2413-9432-2016-5-3-4-8

Biomedical Photonics (Dec 2016)

THE STUDY OF MECHANISMS OF PHOTOINDUCED APOPTOSIS IN THE SKIN MALIGNANT MELANOMA CELL MODEL

M. L. Gelfond,
I. A. Baldueva,
A. S. Barchuk,
G. I. Gafton,
V. V. Anisimov,
Yu. V. Semiletova,
A. V. Novik,
M. Yu. Myasnyankin,
T. L. Nekhaeva,
A. B. Danilova,
E. V. Vorobeychikov,
A. I. Vaalj,
I. G. Gafton

Affiliations

M. L. Gelfond: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia
I. A. Baldueva: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia
A. S. Barchuk: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia
G. I. Gafton: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia Federal State Budgetary Educational Institution of Higher Education Academician I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russian Federation, Saint-Petersburg, Russia
V. V. Anisimov: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia
Yu. V. Semiletova: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia
A. V. Novik: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia
M. Yu. Myasnyankin: North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia
T. L. Nekhaeva: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia
A. B. Danilova: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia
E. V. Vorobeychikov: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia
A. I. Vaalj: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia
I. G. Gafton: Federal State Institution N.N.Petrov Research Institute of Oncology of Federal Agency of High Technology Medical Assistance, Saint-Petersburg, Russia

DOI: https://doi.org/10.24931/2413-9432-2016-5-3-4-8
Journal volume & issue: Vol. 5, no. 3
pp. 4 – 8

Abstract

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The results of the experimental study of immune response of human skin malignant melanoma cells Mel 226 on photodynamic exposure are represented in the article. Photoinduced apoptosis of skin malignant melanoma was studied in vitro. The study showed that irradiation with the agent fotoditazin at dose of 0.5–2.5 µg/ml (6 and 10 min exposure 30 min before irradiation; irradiation parameters: wavelength of 662 nm, total light dose from 40 to 60 J/cm2) induced early apoptosis. The increase of the time of laser irradiation signiﬁcantly accelerates the conversion of photosensitized tumor cells from early to late apoptosis.

Published in Biomedical Photonics

ISSN: 2413-9432 (Print)
Publisher: Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
Country of publisher: Russian Federation
LCC subjects: Medicine: Medicine (General): Medical technology
Website: http://www.pdt-journal.com/

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