Indian Journal of Dental Research (Jan 2012)

Dental stem cells: Dentinogenic, osteogenic, and neurogenic differentiation and its clinical cell based therapies

  • Gurlal Singh Brar,
  • Ravi Sher Singh Toor

DOI
https://doi.org/10.4103/0970-9290.102239
Journal volume & issue
Vol. 23, no. 3
pp. 393 – 397

Abstract

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Each year approximately 400 billion is spent treating Americans suffering some type of tissue loss or end-stage organ failure. This includes millions of dental and oral craniofacial procedure, ranging from tooth restorations to major reconstruction of facial soft and mineralized tissue. Recently, a population of putative post-natal stem cells in human dental pulp (DPSCs) has been identified within the "cell- rich zone" of dental pulp. The other type of stem cells from human exfoliated deciduous teeth (SHED) was identified to be a population of highly proliferative, clonogenic cells. Dental Pulp Stem Cells (DPSCs) can not only be derived from a very accessible tissue resource like SHED but are also capable of providing enough cells for potential cell-based therapies.

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