Effects of Yunnan Baiyao retention enema combined with mesalazine enteric-coated tablets and bifidobacterium triple viable capsules for treating ulcerative colitis

Abstract

[Objectives] To determine the effects of Yunnan Baiyao retention enema combined with mesalazine enteric-coated tablets and bifidobacterium triple viable capsules for treating ulcerative colitis (UC). [Methods] Sixty patients with UC treated at our hospital between January 2020 and June 2021 were randomly divided into the treatment group (n=30) and the control group (n=30). Patients in the treatment group received mesalazine enteric-coated tablets and bifidobacterium triple viable capsules combined with Yunnan Baiyao retention enema. Patients in the control group received mesalazine enteric-coated tablets and starch placebo capsules combined with placebo retention enema. The followings were compared between the two groups: the clinical effectiveness, the endoscopic score, disease activity index (DAI), levels of inflammatory indicators [C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), transforming growth factor β (TGF-β), interleukin 10 (IL-10), interferon γ (IFN-γ)] and immune indicators [immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA)]. [Results] The effectiveness of treatment group was significantly better than control group (P0.05). The IgM level at 8 weeks after treatment was similar between the two groups (P>0.05). In both groups, DAI, the endoscopic score, and levels of CRP, ESR, IFN-γ, IgG, and IgA were significantly lower than those before treatment, and their levels were significantly lower in the treatment group than in the control group (P<0.05). On the other hand, IL-10, and TGF-β at 8 weeks after treatment were significantly higher than those before treatment in both groups. Their levels were significantly higher in the treatment group than in the control group (P<0.05). [Conclusion] Yunnan Baiyao retention enema combined with mesalazine enteric-coated tablets and bifidobacterium triple viable capsules can alleviate inflammatory responses in the treatment of UC, and has a good clinical effect.

Keywords

• ulcerative colitis
• mesalazine enteric-coated tablets
• bifidobacterium triple viable capsules
• yunnan baiyao
• retention enema