RITUXIMAB EFFICACY IN TREATING SYSTEMIC JUVENILE ARTHRITIS REFRACTORY TO TRADITIONAL IMMUNOSUPPRESSANT AND TNF BLOCKER THERAPY

Voprosy Sovremennoj Pediatrii. 2007;6(3):94-100

 

Journal Homepage

Journal Title: Voprosy Sovremennoj Pediatrii

ISSN: 1682-5527 (Print); 1682-5535 (Online)

Publisher: "Paediatrician" Publishers LLC

Society/Institution: The Union of Pediatricians of Russia

LCC Subject Category: Medicine: Pediatrics

Country of publisher: Russian Federation

Language of fulltext: English, Russian

Full-text formats available: PDF

 

AUTHORS

E.I. Alexeeva (Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow)
S.S. Akulova (Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow)
E.L. Semikina (Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow)
T.M. Bzarova (Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow)
K.B. Isaeva (Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 8 weeks

 

Abstract | Full Text

<em>The article describes the clinical case of a difficult systemic juvenile arthritis refractory to traditional immunosuppressant and TNF blocker therapy. The disease was characterized by such extra-articulate manifestations as fever, lymphadenopathy, hepatolienomegaly, polyorrhymenitis, generalized joint affection and high laboratory activity indicators (ESR, CRP). The inclusion of rituximab stimulated the remission of systemic manifestations and the joint syndrome, as well as normalized the laboratory disease activity indicators. The therapeutic effect duration was 22 weeks upon the initial infusion of rituximab. The results demonstrate that rituximab is a promising medication for treating systemic juvenile arthritis children.</em><br /><strong><em>Key words: children, treatment, rituximab, juvenile arthritis.</em></strong>