Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion

Ruiqi Cai; Lingyun Wang; Xiong Liu; Marek Michalak; Jingfeng Tang; Ji-Bin Peng; Xing-Zhen Chen

doi:10.1038/s42003-021-02521-3

Communications Biology (Aug 2021)

Auto-inhibitory intramolecular S5/S6 interaction in the TRPV6 channel regulates breast cancer cell migration and invasion

Ruiqi Cai,
Lingyun Wang,
Xiong Liu,
Marek Michalak,
Jingfeng Tang,
Ji-Bin Peng,
Xing-Zhen Chen

Affiliations

Ruiqi Cai: Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta
Lingyun Wang: Division of Nephrology, Department of Medicine, Nephrology Research and Training Center, University of Alabama at Birmingham
Xiong Liu: Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta
Marek Michalak: Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta
Jingfeng Tang: National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology
Ji-Bin Peng: Division of Nephrology, Department of Medicine, Nephrology Research and Training Center, University of Alabama at Birmingham
Xing-Zhen Chen: Department of Physiology, Faculty of Medicine and Dentistry, University of Alberta

DOI: https://doi.org/10.1038/s42003-021-02521-3
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Cai et al discover an auto-inhibitory interaction between the S5 and S6 helices in the calcium-selective channel TRPV6. Molecular dynamics simulations predict that pathogenic mutation R532Q in S5 results in channel gain-of-function, which is confirmed in breast cancer migration, invasion and apoptosis assays.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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