Recent advances in understanding and managing gout [version 1; referees: 2 approved]

Abstract

Gout is the most common crystal arthropathy and the leading cause of inflammatory arthritis. It is associated with functional impairment and, for many, a diminished health-related quality of life. Numerous studies have demonstrated the impact of gout and its associated conditions on patient morbidity and mortality. Unfortunately, gout remains under-diagnosed and under-treated in the general community. Despite major advances in treatment strategies, as many as 90% of patients with gout are poorly controlled or improperly managed and their hyperuricemia and recurrent flares continue. The introduction of novel urate-lowering therapies, new imaging modalities, and a deeper understanding of the pathogenesis of gout raise the possibility of better gout care and improved patient outcomes. Here, we spotlight recent advances in the diagnosis and management of gout and discuss novel therapeutics in gout treatment.

Keywords

• Cognitive Neurology & Dementia
• Dermatologic Pharmacology
• Hereditary, Genetic & Developmental Aspects of Nephrology
• Immune & Inflammatory Rheumatic Diseases (incl. Arthritis)
• Medical Genetics
• Movement Disorders
• Multiple Sclerosis & Related Disorders
• Musculoskeletal Pharmacology
• Neuromuscular Diseases
• Pathophysiology of Chronic Kidney Disease (CKD)
• Renal Function & Transport Physiology
• Renal Pharmacology