Ferroptosis: A New Strategy for Cancer Therapy

Yu Chen; Zhihua Fan; Shen Hu; Chengchao Lu; Yi Xiang; Shuzhi Liao

doi:10.3389/fonc.2022.830561

Frontiers in Oncology (Feb 2022)

Ferroptosis: A New Strategy for Cancer Therapy

Yu Chen,
Zhihua Fan,
Shen Hu,
Chengchao Lu,
Yi Xiang,
Shuzhi Liao

Affiliations

Yu Chen: epartment of Pediatric Surgery, Guangdong Women and Children Hospital, Guangzhou, China
Zhihua Fan: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
Shen Hu: Department of Obstetrics, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Chengchao Lu: epartment of Pediatric Surgery, Guangdong Women and Children Hospital, Guangzhou, China
Yi Xiang: epartment of Pediatric Surgery, Guangdong Women and Children Hospital, Guangzhou, China
Shuzhi Liao: epartment of Pediatric Surgery, Guangdong Women and Children Hospital, Guangzhou, China

DOI: https://doi.org/10.3389/fonc.2022.830561
Journal volume & issue: Vol. 12

Abstract

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Ferroptosis is a newly discovered form of iron-dependent cell death, which is different from other death forms. The main characteristics of ferroptosis are: (1) Amino acid metabolism. (2) Iron metabolism; (3) Lipid metabolism and Reactive oxygen species (ROS). Ferroptosis is related to the occurrence and development of a variety of cancers, especially in the drug resistance. This article reviews the research progress of iron death in tumors, and provides a theoretical reference for its further research and clinical application.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

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