Template synthesis, characterization, and antimicrobial activity of a new lead (II) Schiff base complex

Abstract

A novel lead (II) complex of Schiff base containing three bipyridine units was synthesized by the template reaction between a new amine compound, 6-methyl-6′-(2-aminophenoxymethyl)-2,2′-bipyridine, and 2,2′-bipyridine-6,6′-dicarboxaldehyde in the presence of a Pb(II) perchlorate ion. The new amino compound and Schiff base complex, [PbL](ClO4)2·2H2O, were characterized by using matrix-assisted laser desorption/ionization with time-of-flight mass spectroscopy, FAR FT-IR, UV/visible spectroscopy, 1H NMR, elemental analyses (CHN), and molar conductivity measurements. Then the synthesized complex was screened in vitro for its antibacterial and antifungal activities against three Gram-negative and two Gram-positive bacteria and also against Candida albicans as a fungus by the microdilution broth method as a minimal inhibitory concentration. [PbL](ClO4)2·2H2O exhibits moderate activity on Staphylococcus aureus and Listeria monocytogenes when compared with standard drug and also shows moderate antifungal activity on the fungus Candida albicans.

Keywords

• antimicrobial activity
• lead (ii)
• schiff base
• template reaction