Nature Communications (May 2020)

Transcript isoform sequencing reveals widespread promoter-proximal transcriptional termination in Arabidopsis

  • Quentin Angelo Thomas,
  • Ryan Ard,
  • Jinghan Liu,
  • Bingnan Li,
  • Jingwen Wang,
  • Vicent Pelechano,
  • Sebastian Marquardt

DOI
https://doi.org/10.1038/s41467-020-16390-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Gene isoforms result from variable transcription start sites (TSSs) and polyadenylation sites (PASs) at the end of transcripts. Here, the authors perform transcript isoform sequencing and find widespread promoter- proximal transcriptional termination in Arabidopsis, suggesting this may represent a checkpoint that regulates plant gene expression.