Diagnostic challenge and survival analysis of pulmonary oligometastases and primary lung cancer in breast cancer patients

Abstract

Abstract Background The aim of this study was to compare breast cancer patients with pulmonary oligometastases (POM) and primary lung cancer (PLC) and to assess whether there were differences in clinical features, CT features, and survival outcomes between the two groups. Methods From January 2010 to December 2021, the clinical records of 437 with malignant pulmonary nodules who had breast cancer patients were reviewed. POM was identified in 45 patients and PLC in 43 patients after the initial detection of pulmonary nodules. The clinicopathological characteristics, CT appearance of pulmonary nodules, and survival of the two groups were compared. Results Stage II to IV breast tumors (p < 0.001), high pathological grade of breast cancer (p = 0.001), low proportion of luminal‐type breast cancer (p = 0.003), and the higher serum CYFRA 21‐1 level (p = 0.046) were the clinical characteristics of pulmonary nodules suggestive of POM rather than PLC. The CT features of lung nodules indicative of PLC rather than POM were the subsolid component (p < 0.001), lobulation (p = 0.010), air bronchogram (p < 0.001) and pleural indentation (p = 0.004). Ten‐year survival rate for PLC was 93.2%, which was higher compared with 57.8% in those with POM (p = 0.001). Conclusions Elevated serum CYFRA 21‐1 levels and late‐stage breast cancer may be beneficial for the diagnosis of POM. CT imaging appearances of the subsolid component, lobulation, air bronchogram, and pleural indentation increase the likelihood of PLC. Breast cancer patients with PLC presented better survival with attentive monitoring than those with POM.

Keywords

• breast cancer
• primary lung cancer
• pulmonary oligometastases
• second primary malignant neoplasms