Chemical zymogens for the protein cysteinome

Mireia Casanovas Montasell; Pere Monge; Sheiliza Carmali; Livia Mesquita Dias Loiola; Dante Guldbrandsen Andersen; Kaja Borup Løvschall; Ane Bretschneider Søgaard; Maria Merrild Kristensen; Jean Maurice Pütz; Alexander N. Zelikin

doi:10.1038/s41467-022-32609-1

Nature Communications (Aug 2022)

Chemical zymogens for the protein cysteinome

Mireia Casanovas Montasell,
Pere Monge,
Sheiliza Carmali,
Livia Mesquita Dias Loiola,
Dante Guldbrandsen Andersen,
Kaja Borup Løvschall,
Ane Bretschneider Søgaard,
Maria Merrild Kristensen,
Jean Maurice Pütz,
Alexander N. Zelikin

Affiliations

Mireia Casanovas Montasell: Department of Chemistry, Aarhus University
Pere Monge: Department of Chemistry, Aarhus University
Sheiliza Carmali: Department of Chemistry, Aarhus University
Livia Mesquita Dias Loiola: Department of Chemistry, Aarhus University
Dante Guldbrandsen Andersen: Department of Chemistry, Aarhus University
Kaja Borup Løvschall: Department of Chemistry, Aarhus University
Ane Bretschneider Søgaard: Department of Chemistry, Aarhus University
Maria Merrild Kristensen: Department of Chemistry, Aarhus University
Jean Maurice Pütz: Department of Chemistry, Aarhus University
Alexander N. Zelikin: Department of Chemistry, Aarhus University

DOI: https://doi.org/10.1038/s41467-022-32609-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Reversible on/off switches for enzyme activity are foundational in nature but are challenging to design using tools of synthetic chemistry. Here the authors design chemical zymogens amenable for activation via biomolecular interactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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