Nature Communications (Jul 2019)
Neutrophils-related host factors associated with severe disease and fatality in patients with influenza infection
- Benjamin M. Tang,
- Maryam Shojaei,
- Sally Teoh,
- Adrienne Meyers,
- John Ho,
- T. Blake Ball,
- Yoav Keynan,
- Amarnath Pisipati,
- Aseem Kumar,
- Damon P. Eisen,
- Kevin Lai,
- Mark Gillett,
- Rahul Santram,
- Robert Geffers,
- Jens Schreiber,
- Khyobeni Mozhui,
- Stephen Huang,
- Grant P. Parnell,
- Marek Nalos,
- Monika Holubova,
- Tracy Chew,
- David Booth,
- Anand Kumar,
- Anthony McLean,
- Klaus Schughart
Affiliations
- Benjamin M. Tang
- Department of Intensive Care Medicine, Nepean Hospital
- Maryam Shojaei
- Department of Intensive Care Medicine, Nepean Hospital
- Sally Teoh
- Department of Intensive Care Medicine, Nepean Hospital
- Adrienne Meyers
- National HIV and Retrovirology Laboratories, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Department of Medical Microbiology and Infectious Disease, University of Manitoba
- John Ho
- National HIV and Retrovirology Laboratories, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Department of Medical Microbiology and Infectious Disease, University of Manitoba
- T. Blake Ball
- National HIV and Retrovirology Laboratories, JC Wilt Infectious Disease Research Centre, Public Health Agency of Canada, Department of Medical Microbiology and Infectious Disease, University of Manitoba
- Yoav Keynan
- Department of Internal Medicine, Medical Microbiology and Community Health Sciences, University of Manitoba
- Amarnath Pisipati
- Department of Chemistry and Biological Chemistry, Harvard University
- Aseem Kumar
- Department of Chemistry and Biochemistry, Laurentian University
- Damon P. Eisen
- Townsville Hospital
- Kevin Lai
- Department of Emergency Medicine, Westmead Hospital
- Mark Gillett
- Department of Emergency Medicine, Royal North Shore Hospital
- Rahul Santram
- Department of Emergency Medicine, St. Vincent Hospital
- Robert Geffers
- Genome Analytics, Helmholtz Centre for Infection Research
- Jens Schreiber
- Otto-von-Guerike University of Magdeburg, Clinic of Pneumology
- Khyobeni Mozhui
- Department of Preventive Medicine, University of Tennessee Health Science Centre
- Stephen Huang
- Department of Intensive Care Medicine, Nepean Hospital
- Grant P. Parnell
- Centre for Immunology and Allergy Research, The Westmead Institute for Medical Research
- Marek Nalos
- Department of Intensive Care Medicine, Nepean Hospital
- Monika Holubova
- Biomedical Centre, Medical Faculty Plzen, Charles University Prague
- Tracy Chew
- Sydney Informatic Hub, The University of Sydney
- David Booth
- Centre for Immunology and Allergy Research, The Westmead Institute for Medical Research
- Anand Kumar
- Section of Critical Care Medicine and Section of Infectious Diseases, Departments of Medicine, Medical Microbiology and Pharmacology, University of Manitoba
- Anthony McLean
- Department of Intensive Care Medicine, Nepean Hospital
- Klaus Schughart
- Department of Infection Genetics, Helmholtz Centre for Infection Research
- DOI
- https://doi.org/10.1038/s41467-019-11249-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Identification of host factors associated with severe influenza infection could provide insights into treatment options. Here, the authors provide transcriptomic analyses of blood from >100 influenza infected patients and show that changes in circulating neutrophils are associated with severe influenza infection.
