Mouse embryo geometry drives formation of robust signaling gradients through receptor localization

Zhechun Zhang; Steven Zwick; Ethan Loew; Joshua S. Grimley; Sharad Ramanathan

doi:10.1038/s41467-019-12533-7

Nature Communications (Oct 2019)

Mouse embryo geometry drives formation of robust signaling gradients through receptor localization

Zhechun Zhang,
Steven Zwick,
Ethan Loew,
Joshua S. Grimley,
Sharad Ramanathan

Affiliations

Zhechun Zhang: Department of Molecular and Cellular Biology, Harvard University
Steven Zwick: School of Engineering and Applied Sciences, Harvard University
Ethan Loew: Department of Molecular and Cellular Biology, Harvard University
Joshua S. Grimley: Allen Institute for Brain Science
Sharad Ramanathan: Department of Molecular and Cellular Biology, Harvard University

DOI: https://doi.org/10.1038/s41467-019-12533-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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How receptor localization affects morphogen gradient formation during embryonic development is unclear. Here, the authors study the relationship between the BMP gradient, receptor localization, and compartmentalized geometry in the early mouse embryo, using experimental data and computational simulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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