Nature Communications (Jun 2020)
Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
- Kotaro Kiga,
- Xin-Ee Tan,
- Rodrigo Ibarra-Chávez,
- Shinya Watanabe,
- Yoshifumi Aiba,
- Yusuke Sato’o,
- Feng-Yu Li,
- Teppei Sasahara,
- Bintao Cui,
- Moriyuki Kawauchi,
- Tanit Boonsiri,
- Kanate Thitiananpakorn,
- Yusuke Taki,
- Aa Haeruman Azam,
- Masato Suzuki,
- José R. Penadés,
- Longzhu Cui
Affiliations
- Kotaro Kiga
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Xin-Ee Tan
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Rodrigo Ibarra-Chávez
- Institute of Infection, Immunity & Inflammation, University of Glasgow
- Shinya Watanabe
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Yoshifumi Aiba
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Yusuke Sato’o
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Feng-Yu Li
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Teppei Sasahara
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Bintao Cui
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Moriyuki Kawauchi
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Tanit Boonsiri
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Kanate Thitiananpakorn
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Yusuke Taki
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Aa Haeruman Azam
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- Masato Suzuki
- Antimicrobial Resistance Research Center, National Institute of Infectious Diseases
- José R. Penadés
- Institute of Infection, Immunity & Inflammation, University of Glasgow
- Longzhu Cui
- Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University
- DOI
- https://doi.org/10.1038/s41467-020-16731-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
CRISPR technology is emerging as a potential antimicrobial against antimicrobial-resistant bacteria. Here the authors develop a bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes.
