Nature Communications (Jul 2017)
ATP-dependent modulation of MgtE in Mg2+ homeostasis
- Atsuhiro Tomita,
- Mingfeng Zhang,
- Fei Jin,
- Wenhui Zhuang,
- Hironori Takeda,
- Tatsuro Maruyama,
- Masanori Osawa,
- Ken-ichi Hashimoto,
- Hisashi Kawasaki,
- Koichi Ito,
- Naoshi Dohmae,
- Ryuichiro Ishitani,
- Ichio Shimada,
- Zhiqiang Yan,
- Motoyuki Hattori,
- Osamu Nureki
Affiliations
- Atsuhiro Tomita
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Mingfeng Zhang
- State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center of Genetics and Development, Institute of Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University
- Fei Jin
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University
- Wenhui Zhuang
- State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center of Genetics and Development, Institute of Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University
- Hironori Takeda
- Faculty of Life Science, Kyoto Sangyo University, Kamigamo-motoyama
- Tatsuro Maruyama
- Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo
- Masanori Osawa
- Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo
- Ken-ichi Hashimoto
- Department of Green and Sustainable Chemistry, Tokyo Denki University
- Hisashi Kawasaki
- Department of Green and Sustainable Chemistry, Tokyo Denki University
- Koichi Ito
- Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
- Naoshi Dohmae
- Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science
- Ryuichiro Ishitani
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- Ichio Shimada
- Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo
- Zhiqiang Yan
- State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center of Genetics and Development, Institute of Brain Science, Department of Physiology and Biophysics, School of Life Sciences, Fudan University
- Motoyuki Hattori
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University
- Osamu Nureki
- Department of Biological Sciences, Graduate School of Science, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-017-00082-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Author summary MgtE is an Mg2+ transporter involved in Mg2+ homeostasis. Here, the authors report that ATP regulates the Mg+2-dependent gating of MgtE and use X-ray crystallography combined with functional studies to propose the molecular mechanisms involved in this process.
