SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

Yuchen Zhang; Rui Guo; Sharon H. Kim; Hardik Shah; Shuting Zhang; Jin Hua Liang; Ying Fang; Matteo Gentili; Colin N. O’ Leary; Steven J. Elledge; Deborah T. Hung; Vamsi K. Mootha; Benjamin E. Gewurz

doi:10.1038/s41467-021-21903-z

Nature Communications (Mar 2021)

SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

Yuchen Zhang,
Rui Guo,
Sharon H. Kim,
Hardik Shah,
Shuting Zhang,
Jin Hua Liang,
Ying Fang,
Matteo Gentili,
Colin N. O’ Leary,
Steven J. Elledge,
Deborah T. Hung,
Vamsi K. Mootha,
Benjamin E. Gewurz

Affiliations

Yuchen Zhang: Broad Institute of MIT and Harvard
Rui Guo: Broad Institute of MIT and Harvard
Sharon H. Kim: Broad Institute of MIT and Harvard
Hardik Shah: Broad Institute of MIT and Harvard
Shuting Zhang: Broad Institute of MIT and Harvard
Jin Hua Liang: Broad Institute of MIT and Harvard
Ying Fang: Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign
Matteo Gentili: Broad Institute of MIT and Harvard
Colin N. O’ Leary: Division of Genetics, Brigham and Women’s Hospital, Department of Genetics, Howard Hughes Medical Institute, Program in Virology, Harvard Medical School
Steven J. Elledge: Division of Genetics, Brigham and Women’s Hospital, Department of Genetics, Howard Hughes Medical Institute, Program in Virology, Harvard Medical School
Deborah T. Hung: Broad Institute of MIT and Harvard
Vamsi K. Mootha: Broad Institute of MIT and Harvard
Benjamin E. Gewurz: Broad Institute of MIT and Harvard

DOI: https://doi.org/10.1038/s41467-021-21903-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional level.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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