Nature Communications (Apr 2016)

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers

  • Christopher D. Putnam,
  • Anjana Srivatsan,
  • Rahul V. Nene,
  • Sandra L. Martinez,
  • Sarah P. Clotfelter,
  • Sara N. Bell,
  • Steven B. Somach,
  • Jorge E.S. de Souza,
  • André F. Fonseca,
  • Sandro J. de Souza,
  • Richard D. Kolodner

DOI
https://doi.org/10.1038/ncomms11256
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Here, Richard Kolodner and colleagues use assays in Saccharomyces cerevisiaeto identify 182 genetic modifiers of gross chromosomal rearrangements (GCRs). They also compared these Genome Instability Suppressing (GIS) genes and pathways in human cancer genome, and found many ovarian and colorectal cancer cases have alterations to GIS pathways.