Nature Communications (Nov 2017)

The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors

  • Kevin Boyé,
  • Nadège Pujol,
  • Isabel D Alves,
  • Ya-Ping Chen,
  • Thomas Daubon,
  • Yi-Zong Lee,
  • Stephane Dedieu,
  • Marion Constantin,
  • Lorenzo Bello,
  • Marco Rossi,
  • Rolf Bjerkvig,
  • Shih-Che Sue,
  • Andreas Bikfalvi,
  • Clotilde Billottet

DOI
https://doi.org/10.1038/s41467-017-01686-y
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 20

Abstract

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The chemokine receptor CXCR3-A is expressed in high grade glioma. Here the authors show that CXCR3-A interacts with LPR1, a protein highly expressed in glioma, and this interaction regulates the trafficking of the receptor ultimately impacting on tumour cell migration.